| Character | Description | Item Unlock |
|---|---|---|
| Commando | Dodge 7 Lethal attacks. | Soldier's Syringe |
| Commando | Activate the 3rd teleporter without being hurt once. | Hyper-Threader |
| Enforcer | Block 2000 damage total with your shield. | Spikestrip |
| Enforcer | Stay in Shield Mode for 5 minutes straight (in combat). | Prescriptions |
| Bandit | Kill a boss with Lights Out. | Pillaged Gold |
| Bandit | Reset your cooldowns with Lights Out 15 times consecutively. | The Hit List |
| Huntress | Achieve 200% attack speed. | Hermit's Scarf |
| Huntress | Defeat the Legendary Wisp without taking damage. | Predatory Instincts |
| HAN-D | Kill 10 enemies simultaneously with FORCED_REASSEMBLY. | Arms Race |
| HAN-D | Stay above 70% health for 25 minutes. | Shield Generator |
| Engineer | Detonate 15 Bounding Mine within 5 seconds. | Sticky Bomb |
| Engineer | Kill a boss in 15 seconds or less. | Concussion Grenade |
| Miner | Survive the teleporter event without falling below 50% health. | Panic Mines |
| Miner | Reach level 10 without getting hurt more than once. | Shattering Justice |
| Sniper | Achieve 20 consecutive perfect reloads. | Crudely Drawn Buddy |
| Sniper | 1-shot kill 10 enemies consecutively. | Telescopic Sight |
| Acrid | Spread 10,000 feet of Caustic Sludge. | Toxic Worm |
| Acrid | Spread Epidemic to 25 enemies. | Massive Leech |
| Mercenary | Eviscerate 50 enemies. | Chargefield Generator |
| Mercenary | Beat the game on
Monsoon - MONSOON - difficulty.
For hardcore players. Every bend introduces pain and horrors of the planet. You will die. |
Ancient Scepter |
| Loader | Travel for 20.000 feet using the Hydraulic Gauntlet. | Taser |
| Loader | Kill the Overloading Magma Worm. | Gigantic Amethyst |
| CHEF | SEAR/FLAMBE 20 Sand Crabs. | Interstellar Desk Plant |
| CHEF | Have 20 cleavers in the air simultaneously. | Laser Turbine |
| GLOBAL | Defeat 20 Lemurians in one playthrough. | Gasoline |
| GLOBAL | Complete the 1st stage in under 5 minutes. | Unstable Watch |
| GLOBAL | Survive a boss with less than 20% health. | Lost Doll |
| GLOBAL | Have 4 drone helpers at once. | The Back-Up |
| GLOBAL | Fail a shrine three times in a row. | Paul's Goat Hoof |
| GLOBAL | Kill the Scavenger. | 56 Leaf Clover |
| GLOBAL | Survive 40 minutes. | The Ol' Lopper |
| GLOBAL | Survive in lava for 1 minute straight. | Fireman's Boots |
| GLOBAL | End a Teleporter timer with 0 enemies on the map. | Photon Jetpack |
| GLOBAL | Die 50 times. | Dio's Best Friend |
| GLOBAL | Find the bloated survivor. | Dead Man's Foot
|
| GLOBAL | Obtain 7 Monster Teeth and 1 Guardian Heart. | Alien Head |
| GLOBAL | Reach 650 health. | Bitter Root |
| GLOBAL | Unlock a golden chest with the Explorer's Key. | Captain's Brooch |
| GLOBAL | Deal 5000 damage in one shot. | Glowing Metoerite |
| GLOBAL | Drown 20 Whorls. | Filial Imprinting |
| GLOBAL | Bank 20,000 Gold | Golden Gun
|
| GLOBAL | Collect 4 keycards. | Wicked Ring |
| GLOBAL | Use a health shrine that drops you below 5% health. | Harvester's Scythe |
| GLOBAL | Pass a shrine 4 times in a row. | Snake Eyes |

