The Artificer clearly uses three elements in her skills, Nano(electricity), Ice and Fire. I think she will have an alternate skill for each slot with each element. Those could be:
M1: Ice Bolt, slowing ice shards, stacks up to 4, similar to the other main skills. Maybe this could home, or split into weaker shards on hit.
M2: Charged Firebomb, if the skill is just clicked, the Artificer chucks out a slow ball of flame that detonates on impact and ignites enemies, but the longer it is charged the smaller and faster the ball is, and if fully charged, it becomes a beam of fire instead.
Shift: Nano-clones, Spawn three nano-clones to distract your enemies. They shock enemies when they are damaged.
Shift: Phoenix. Flare in brilliant flame, healing for each enemy damaged and igniting them.
R: Snowball (let's not be too serious, an also I didn't have a great idea for this one) a ball that gathers speed and damage as it rolls on the ground and hits enemies. Homes slighty.